These results identify the gut microbiota as a critical determinant of increased susceptibility to enteric infection during the neonatal period.
The neonatal bacteria enhanced the ability of these protective Clostridiales to colonize the gut. Furthermore, intragastric administration of Clostridiales protected neonatal mice from pathogen infection. Conversely, depletion of Clostridiales abolished colonization resistance in adult mice. Administration of Clostridiales, but not Bacteroidales, restored colonization resistance and abrogated intestinal pathology upon pathogen challenge. The lack of colonization resistance was caused by the absence of Clostridiales in the neonatal microbiota. By colonizing adult germ-free mice with the cecal contents of neonatal and adult mice, we show that the neonatal microbiota is impaired in mediating colonization resistance against two major pathogens causing mortality in neonates. The high susceptibility of neonates to infections has been assumed to be due to immaturity of the immune system, but the mechanism remains unclear. This section also contains links to related websites and 'Mouse Facts' provides informative descriptions of mouse biology.Metabolome analysis of the cecal contents of GF mice and GF mice colonized with dominant gut microbes present in the ceca of neonatal and adult mice The 'Information and Help' section includes an electronic bulletin board for the genetics research community and useful tools for software developers. In addition, MGI contains the Mouse Genome Database (MGD) which gives information on mouse genetic markers, molecular segments, phenotypes and mapping, and the Gene Expression Database (GXD) which holds gene expression data on the laboratory mouse and links to other resources. The Jax Mice database contains lists of mouse models and describes over 2000 strains of genetically defined mice for biomedical research.The Mouse Genome Informatics (MGI) database provides access to various sources of material on mouse genetics and includes an encyclopedia of the mouse genome. The site contains several databases concerning the genetics and biology of the laboratory mouse. This site provides access to various sources of information with details of career opportunities, Jackson Lab courses, conferences and industrial programs.
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